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butabarbital will increase effects of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers could enhance the metabolism of ifosfamide to its Energetic alkylating metabolites.butabarbital will minimize the level or effect of lopinavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Cau